Nanotechnology tools for single-virus particle detection

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Abstract The development and potential application of nanotechnology tools for single-virus particle detection by emergent nanotechnology is likely to revolutionize diagnosis and determining treatment endpoints for life threatening virus infections.

Direct detection of biological macromolecules using semiconducting nanowires or carbon nanotubes for electrical field change measurements is a milestone application in this field. The promise of selective detection at a single particle level stochastic sensing with nanowire or nanotube field-effect transistor-based devices is a major breakthrough for outbreak situations, where a rapid and specific detection of the viral agent allows intervention at public health level.

The same technology would be eminently suitable for bedside diagnosis and therapeutic intervention. Inorganic as well as non-metallic fluorescent materials share the advantages of high photochemical stability, a wide range of light absorption curves and polychromatic emission. Hence, are considered as potential fluorescent nano-probes for SVT. However, there are still some challenges: i clinical false positive rate of some detection methods is still high; ii in the virus tracking process, less adaptability of QDs owing to larger size, flicker, and possible interference with virus function; and iii in vivo tracking of a single virus, in real time needs further refinement.

Wasisto, H. Airborne engineered nanoparticle mass sensor based on a silicon resonant cantilever. Sensor Actuat. In press Hajjam, A. Fabrication and characterization of thermally actuated micromechanical resonators for airborne particle mass sensing: II. Device fabrication and characterization. Chaste, J. A nanomechanical mass sensor with yoctogram resolution. Cagliani, A. Ultrasensitive bulk disk microresonator-based sensor for distributed mass sensing. Ekinci, K. Ultrasensitive nanoelectromechanical mass detection.

Jensen, K. An atomic-resolution nanomechanical mass sensor. Li, M. Ultra-sensitive NEMS-based cantilevers for sensing, scanned probe and very high-frequency applications. Hinds, W. Fuchs, N. The mechanics of aerosols Pergamon Press, Yeh, H. Aerosol filtration by fibrous filters - I. Aerosol Sci. ADS Google Scholar. Ingham, D. The diffusional deposition of fibrous filters. Langmuir 12, — Google Scholar. Fardi, B. Efficiency of fibrous filters with rectangular fibers efficiency of fibrous filters with rectangular fibers.

Schmid, S. Real-time particle mass spectrometry based on resonant micro strings. Sensors 10, — Orts-Gil, G. Characterisation of silica nanoparticles prior to in vitro studies: from primary particles to agglomerates. Lee, K. A Contribution to the Theory.

Faraday Symp. Damping mechanisms in high-Q micro and nanomechanical string resonators. B 84, 1—6 Download references. You can also search for this author in PubMed Google Scholar. Reprints and Permissions. Real-time single airborne nanoparticle detection with nanomechanical resonant filter-fiber. Sci Rep 3, Download citation. Received : 20 November Accepted : 31 January Published : 15 February Anyone you share the following link with will be able to read this content:.

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